Well it is actually possible because there are number of such pre built CSS frameworks available on the internet. Out of which Twitter Bootstrap and foundation are two of the most popular ones. Both are open source and thus can be downloaded and used for free. However both have a remarkable difference in popularity even though both are equally good as CSS framework.
This popularity difference is visible in twitter statistics of both these frameworks that is shown in the infographic below. Twitter Bootstrap, being the more popular out of the two, has significantly more followers than Zurb’s Foundation Framework. However the followers of foundation are more active with better engagement rate and significantly more tweets per week than than bootstrap. Total number of tweets is also higher for Foundation when compared to bootstrap.
In all the competition is very tense and no one can say what the future holds. But for now you have two great options to use as CSS framework for creating quality websites. Choosing the right one out of the two however, is still a tough topic. So we will advise you to go with your instincts and use what the one you find easy to use.